A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication | Zendy

Darren Moss | Zendy; Paul Curley | Zendy; Allison E. Shone | Zendy; Marco Siccardi | Zendy; Andrew Owen | Zendy

Open Access

A multisystem investigation of raltegravir association with intestinal tissue: implications for pre-exposure prophylaxis and eradication

Author(s) -

Darren Moss,

Paul Curley,

Allison E. Shone,

Marco Siccardi,

Andrew Owen

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku312

Subject(s) - raltegravir , in vivo , ex vivo , pharmacology , small intestine , pharmacokinetics , in silico , biology , chemistry , biochemistry , immunology , microbiology and biotechnology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , gene

Recent clinical data have suggested high raltegravir concentrations in gut tissue after oral administration, with implications for treatment and prevention. We have used in silico, in vitro, ex vivo and in vivo models to further investigate the accumulation of raltegravir in gut tissue.

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