Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study | Zendy

Takeshi Nishijima | Zendy; K. Tsuchiya | Zendy; Noriko Tanaka | Zendy; Akane Joya | Zendy; Yohei Hamada | Zendy; Daiki Mizushima | Zendy; Toshio Aoki | Zendy; Kôji Watanabe | Zendy; Ei Kinai | Zendy; Hirokazu Honda | Zendy; Hirohisa Yazaki | Zendy; Junko Tanuma | Zendy; K. Tsukada | Zendy; Katsuji Teruya | Zendy; Yoshimi Kikuchi | Zendy; Shinichi Oka | Zendy; Hiroyuki Gatanaga | Zendy

Open Access

Single-nucleotide polymorphisms in the UDP-glucuronosyltransferase 1A-3' untranslated region are associated with atazanavir-induced nephrolithiasis in patients with HIV-1 infection: a pharmacogenetic study

Author(s) -

Takeshi Nishijima,

K. Tsuchiya,

Noriko Tanaka,

Akane Joya,

Yohei Hamada,

Daiki Mizushima,

Toshio Aoki,

Kôji Watanabe,

Ei Kinai,

Hirokazu Honda,

Hirohisa Yazaki,

Junko Tanuma,

K. Tsukada,

Katsuji Teruya,

Yoshimi Kikuchi,

Shinichi Oka,

Hiroyuki Gatanaga

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku304

Subject(s) - atazanavir , pharmacogenetics , single nucleotide polymorphism , ugt2b7 , genetics , biology , virology , glucuronosyltransferase , genotype , medicine , human immunodeficiency virus (hiv) , pharmacology , gene , glucuronidation , antiretroviral therapy , viral load , in vitro , microsome

Ritonavir-boosted atazanavir (atazanavir/ritonavir) is a widely used antiretroviral drug, though it can potentially cause nephrolithiasis. The aim of this study was to determine the relationship between polymorphisms in genes encoding proteins involved in metabolism and transportation of atazanavir, and atazanavir/ritonavir-induced nephrolithiasis in HIV-1-infected patients treated with atazanavir/ritonavir.

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