Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag-protease genes | Zendy

Katherine A. Sutherland | Zendy; Jean L. Mbisa | Zendy; Jade Ghosn | Zendy; MarieLaure Chaix | Zendy; Isabelle Cohen-Codar | Zendy; Stéphane Hué | Zendy; Jean François Delfraissy | Zendy; Constance Delaugerre | Zendy; Ravindra K. Gupta | Zendy

Open Access

Phenotypic characterization of virological failure following lopinavir/ritonavir monotherapy using full-length gag-protease genes

Author(s) -

Katherine A. Sutherland,

Jean L. Mbisa,

Jade Ghosn,

MarieLaure Chaix,

Isabelle Cohen-Codar,

Stéphane Hué,

Jean François Delfraissy,

Constance Delaugerre,

Ravindra K. Gupta

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku296

Subject(s) - lopinavir , genotyping , ritonavir , lopinavir/ritonavir , context (archaeology) , virology , biology , protease , genetics , gene , phenotype , genotype , virus , viral load , paleontology , enzyme , biochemistry , antiretroviral therapy

Major protease mutations are rarely observed following first-line failure with PIs and interpretation of genotyping results in this context may be difficult. We performed extensive phenotyping of viruses from five patients failing lopinavir/ritonavir monotherapy in the MONARK study without major PI mutations by standard genotyping.

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