Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19 | Zendy

Rosalba Perrone | Zendy; Elena Butovskaya | Zendy; Dirk Daelemans | Zendy; Giorgio Palù | Zendy; Christophe Pannecouque | Zendy; Sara N. Richter | Zendy

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Anti-HIV-1 activity of the G-quadruplex ligand BRACO-19

Author(s) -

Rosalba Perrone,

Elena Butovskaya,

Dirk Daelemans,

Giorgio Palù,

Christophe Pannecouque,

Sara N. Richter

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku280

Subject(s) - biology , reverse transcriptase , dna , transcription (linguistics) , g quadruplex , rna , microbiology and biotechnology , virology , biochemistry , gene , linguistics , philosophy

A dynamic G-quadruplex region has been previously shown to form in the long terminal repeat (LTR) promoter of the HIV-1 integrated DNA genome. Inhibition of promoter activity and antiviral effects have been observed when this region was stabilized by BRACO-19, a trisubstituted acridine derivative that binds G-quadruplexes. Here, we aimed at characterizing the antiviral mechanism of action of BRACO-19 by analysing its activity towards a broad range of HIV-1 strains, host cells and infection modes.

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