Cost-efficient HIV-1 drug resistance surveillance using multiplexed high-throughput amplicon sequencing: implications for use in low- and middle-income countries | Zendy

Hayri Ekici | Zendy; S. D. Rao | Zendy; Anders Sönnerborg | Zendy; VL Ramprasad | Zendy; Ravindra K. Gupta | Zendy; Ujjwal Neogi | Zendy

Open Access

Cost-efficient HIV-1 drug resistance surveillance using multiplexed high-throughput amplicon sequencing: implications for use in low- and middle-income countries

Author(s) -

Hayri Ekici,

S. D. Rao,

Anders Sönnerborg,

VL Ramprasad,

Ravindra K. Gupta,

Ujjwal Neogi

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku278

Subject(s) - amplicon , throughput , drug resistance , human immunodeficiency virus (hiv) , drug , virology , medicine , biology , computer science , polymerase chain reaction , pharmacology , genetics , gene , telecommunications , wireless

Increased trends of primary drug resistance mutations (DRMs) among treatment-naive HIV-1-infected patients in low- and middle-income countries (LMICs) and the non-availability of pre-antiretroviral therapy (ART) genotypic resistance testing (GRT) may severely affect future therapeutic outcomes. The main objective of this study was therefore to develop a simplified, cost- and labour-efficient but high-throughput GRT protocol to be applied in the large-scale surveillance of DRMs in LMICs.

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