Increased expression of SAMHD1 in a subset of HIV-1 elite controllers | Zendy

Eva RiveiraMuñoz | Zendy; A. Ruiz | Zendy; Eduardo Pauls | Zendy; Marc Permanyer | Zendy; Roger Badía | Zendy; Beatriz Mothe | Zendy; Manuel Crespo | Zendy; Bonaventura Clotet | Zendy; Christian Brander | Zendy; Ester Ballana | Zendy; José A. Esté | Zendy

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Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

Author(s) -

Eva RiveiraMuñoz,

A. Ruiz,

Eduardo Pauls,

Marc Permanyer,

Roger Badía,

Beatriz Mothe,

Manuel Crespo,

Bonaventura Clotet,

Christian Brander,

Ester Ballana,

José A. Esté

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku276

Subject(s) - samhd1 , flow cytometry , cd8 , biology , human immunodeficiency virus (hiv) , viral replication , cd3 , virology , immunology , immune system , reverse transcriptase , virus , genetics , gene , rna

SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We have shown that p21 affects HIV replication through its effect on SAMHD1. Thus, we aimed at evaluating the expression of SAMHD1 and p21 in different HIV+ phenotypic groups.

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