Open AccessTNF- levels in HIV-infected patients after long-term suppressive cART persist as high as in elderly, HIV-uninfected subjects
Author(s) -
Rebeca S. de Pablo-Bernal,
Ezequiel RuizMateos,
Isaac Rosado,
Beatriz Domínguez-Molina,
Ana Isabel Álvarez-Ríos,
Antonio Carrillo-Vico,
Rafael de la Rosa,
J. Delgado,
María Ángeles MuñozFernández,
Manuel Leal,
Sara FerrandoMartínez
Publication year - 2014
Publication title -
the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dku263
Subject(s) - cart , medicine , immunology , tumor necrosis factor alpha , inflammation , cohort , ageing , immunosenescence , interferon , immune system , mechanical engineering , engineering
Chronic and systemic inflammatory alterations occur in HIV-infected patients and elderly uninfected subjects and in both scenarios these alterations are associated with the development of chronic morbidities and mortality. However, whether the levels of inflammatory alterations in untreated HIV-infected patients and elderly individuals are similar is unknown. Moreover, whether long-term antiretroviral therapy normalizes inflammatory alterations compared with HIV-uninfected persons of different age is not known.