Systemic absorption of nasally administered tobramycin and colistin in patients with cystic fibrosis | Zendy

M.C. Berkhout | Zendy; A.J. van Velzen | Zendy; Daan J. Touw | Zendy; B Kok | Zendy; Wytske J. Fokkens | Zendy; Harry Heijerman | Zendy

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Systemic absorption of nasally administered tobramycin and colistin in patients with cystic fibrosis

Author(s) -

M.C. Berkhout,

A.J. van Velzen,

Daan J. Touw,

B Kok,

Wytske J. Fokkens,

Harry Heijerman

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku239

Subject(s) - tobramycin , cystic fibrosis , colistin , medicine , absorption (acoustics) , antibiotics , microbiology and biotechnology , gentamicin , biology , physics , acoustics

In cystic fibrosis (CF) patients the paranasal sinuses can constitute a niche for bacteria, which can migrate to the lungs. Nasal administration of antibiotics may be effective, but safety of this treatment has to be established first. The objective of this study was to investigate the systemic absorption of nasally administered tobramycin, colistin (administered as colistin sulfomethate sodium; CMS) and a combination of both drugs using systemic absorption as surrogate for safety. In addition, tolerability of the nasal irrigations was examined.

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