Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C -lactamase enzyme | Zendy

Sushmita D. Lahiri | Zendy; R.A. Giacobbe | Zendy; Michele Johnstone | Zendy; Richard A. Alm | Zendy

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Activity of avibactam against Enterobacter cloacae producing an extended-spectrum class C -lactamase enzyme

Author(s) -

Sushmita D. Lahiri,

R.A. Giacobbe,

Michele Johnstone,

Richard A. Alm

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku237

Subject(s) - enterobacter cloacae , avibactam , microbiology and biotechnology , enterobacter , beta lactamase inhibitors , ceftazidime/avibactam , enterobacteriaceae , enterobacteriaceae infections , chemistry , enzyme , klebsiella pneumoniae , bacterial protein , biology , escherichia coli , antibiotics , bacteria , biochemistry , genetics , gene

Extended-spectrum AmpC (ESAC) β-lactamase enzymes, which are either chromosomally encoded or plasmid encoded, have minor structural changes that broaden their substrate hydrolysis profile. The derepressed AmpC enzyme found once in Enterobacter cloacae CHE was shown to contain a six residue deletion in the H-10 helix in close proximity to the active site. Avibactam is a non-β-lactam inhibitor of Ambler class A, class C and some class D β-lactamases that is in clinical development with several β-lactam agents. It has been shown to inhibit AmpC enzymes, but its microbiological activity against isolates carrying different ESAC enzymes is less well understood.

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