Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family | Zendy

Geoffrey Férir | Zendy; Dana Huskens | Zendy; Sam Noppen | Zendy; Leonardus M. I. Koharudin | Zendy; Angela M. Gronenborn | Zendy; Dominique Schols | Zendy

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Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family

Author(s) -

Geoffrey Férir,

Dana Huskens,

Sam Noppen,

Leonardus M. I. Koharudin,

Angela M. Gronenborn,

Dominique Schols

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku220

Subject(s) - biology , virology , peanut agglutinin , syncytium , monoclonal antibody , lectin , microbiology and biotechnology , antibody , virus , immunology

Oscillatoria agardhii agglutinin homologue (OAAH) proteins belong to a recently discovered lectin family. The founding member OAA and a designed hybrid OAAH (OPA) recognize similar but unique carbohydrate structures of Man-9, compared with other antiviral carbohydrate-binding agents (CBAs). These two newly described CBAs were evaluated for their inactivating properties on HIV replication and transmission and for their potential as microbicides.

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