Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance | Zendy

Cláudia P. Muniz | Zendy; Marcelo A. Soares | Zendy; André F. Santos | Zendy

Open Access

Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance

Author(s) -

Cláudia P. Muniz,

Marcelo A. Soares,

André F. Santos

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku214

Subject(s) - mutation , biology , drug resistance , genetics , reverse transcriptase , human immunodeficiency virus (hiv) , genotype , genetic variation , virology , gene , polymerase chain reaction

Interpretation of drug resistance mutation (DRM) has been based solely on HIV-1 subtype B. Reverse transcriptase (RT) C-terminal domains have been disregarded in resistance interpretation, as their clinical relevance is still controversial. We determined the emergence of DRM in RT C-terminal domains of different HIV-1 subtypes, the genetic barrier for the acquisition of these DRM and their temporal appearance with 'classical' RT inhibitor (RTI) mutations.

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