Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae | Zendy

Shyamasree De Majumdar | Zendy; Jing Yu | Zendy; James Spencer | Zendy; Irina G. Tikhonova | Zendy; Thamarai Schneiders | Zendy

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Molecular basis of non-mutational derepression of ramA in Klebsiella pneumoniae

Author(s) -

Shyamasree De Majumdar,

Jing Yu,

James Spencer,

Irina G. Tikhonova,

Thamarai Schneiders

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku203

Subject(s) - derepression , klebsiella pneumoniae , locus (genetics) , genetics , biology , regulator , gene , tetracycline , repressor , gene expression , escherichia coli , antibiotics , psychological repression

The ram locus, consisting of the romA-ramA genes, is repressed by the tetracycline-type regulator RamR, where regulation is abolished due to loss-of-function mutations within the protein or ligand interactions. The aim of this study was to determine whether the phenothiazines (chlorpromazine and thioridazine) directly interact with RamR to derepress ramA expression.

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