In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy | Zendy

Ilse D. Jacobsen | Zendy; Anja Lüttich | Zendy; Oliver Kurzai | Zendy; Bernhard Hube | Zendy; Matthias Brock | Zendy

Open Access

In vivo imaging of disseminated murine Candida albicans infection reveals unexpected host sites of fungal persistence during antifungal therapy

Author(s) -

Ilse D. Jacobsen,

Anja Lüttich,

Oliver Kurzai,

Bernhard Hube,

Matthias Brock

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku198

Subject(s) - candida albicans , in vivo , caspofungin , biology , corpus albicans , microbiology and biotechnology , fluconazole , antifungal

Candida albicans is an important fungal pathogen that can cause life-threatening disseminated infections. To determine the efficacy of therapy in murine models, a determination of renal fungal burden as cfu is commonly used. However, this approach provides only a snapshot of the current situation in an individual animal and cryptic sites of infection may easily be missed. Thus, we aimed to develop real-time non-invasive imaging to monitor infection in vivo.

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