Emergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe | Zendy

Dennis Nurjadi | Zendy; Adesola Olalekan | Zendy; Franziska Layer | Zendy; Adebayo Shittu | Zendy; Abraham Alabi | Zendy; Beniam Ghebremedhin | Zendy; Frieder Schaumburg | Zendy; Jonas Hofmann-Eifler | Zendy; P.J.J. Van Genderen | Zendy; Éric Caumes | Zendy; Ralf Fleck | Zendy; Frank P. Mockenhaupt | Zendy; Mathias Herrmann | Zendy; Winfried V. Kern | Zendy; Salim Abdulla | Zendy; Martin P. Grobusch | Zendy; Peter G. Kremsner | Zendy; Christiane Wolz | Zendy; Philipp Zanger | Zendy

Open Access

Emergence of trimethoprim resistance gene dfrG in Staphylococcus aureus causing human infection and colonization in sub-Saharan Africa and its import to Europe

Author(s) -

Dennis Nurjadi,

Adesola Olalekan,

Franziska Layer,

Adebayo Shittu,

Abraham Alabi,

Beniam Ghebremedhin,

Frieder Schaumburg,

Jonas Hofmann-Eifler,

P.J.J. Van Genderen,

Éric Caumes,

Ralf Fleck,

Frank P. Mockenhaupt,

Mathias Herrmann,

Winfried V. Kern,

Salim Abdulla,

Martin P. Grobusch,

Peter G. Kremsner,

Christiane Wolz,

Philipp Zanger

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku174

Subject(s) - colonization , staphylococcus aureus , trimethoprim , microbiology and biotechnology , biology , staphylococcal infections , antibiotic resistance , gene , antibiotics , bacteria , genetics

Co-trimoxazole (trimethoprim/sulfamethoxazole) is clinically valuable in treating skin and soft tissue infections (SSTIs) caused by community-associated methicillin-resistant Staphylococcus aureus (MRSA). The genetic basis of emerging trimethoprim/sulfamethoxazole resistance in S. aureus from Africa is unknown. Such knowledge is essential to anticipate its further spread. We investigated the molecular epidemiology of trimethoprim resistance in S. aureus collected in and imported from Africa.

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