Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir | Zendy

Diarmaid J. Murphy | Zendy; Delphine Desjardins | Zendy; Nathalie DereuddreBosquet | Zendy; Patricia Brochard | Zendy; Ludivine Perrot | Zendy; Alain Pruvost | Zendy; Roger Le Grand | Zendy; Ole Lagatie | Zendy; Leen Vanhooren | Zendy; Maxim Feyaerts | Zendy; Jens Van Roey | Zendy; Karl Malcolm | Zendy

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Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir

Author(s) -

Diarmaid J. Murphy,

Delphine Desjardins,

Nathalie DereuddreBosquet,

Patricia Brochard,

Ludivine Perrot,

Alain Pruvost,

Roger Le Grand,

Ole Lagatie,

Leen Vanhooren,

Maxim Feyaerts,

Jens Van Roey,

Karl Malcolm

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku160

Subject(s) - darunavir , microbicide , chemistry , vaginal ring , pharmacology , medicine , population , viral load , virology , human immunodeficiency virus (hiv) , environmental health , family planning , antiretroviral therapy , research methodology

Combination microbicide vaginal rings may be more effective than single microbicide rings at reducing/preventing sexual transmission of HIV. Here, we report the pre-clinical development and macaque pharmacokinetics of matrix-type silicone elastomer vaginal rings containing dapivirine and darunavir.

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