Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar | Zendy

Bhavna Gupta | Zendy; Shuhui Xu | Zendy; Zenglei Wang | Zendy; Ling Sun | Zendy; Jun Miao | Zendy; Liwang Cui | Zendy; Zhaoqing Yang | Zendy

Open Access

Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar

Author(s) -

Bhavna Gupta,

Shuhui Xu,

Zenglei Wang,

Ling Sun,

Jun Miao,

Liwang Cui,

Zhaoqing Yang

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku125

Subject(s) - plasmodium falciparum , biology , mefloquine , genetics , drug resistance , multiple drug resistance , gene , lumefantrine , virology , malaria , artemisinin , immunology

Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) has recently emerged as an important determinant of drug resistance and mutations in the gene have been associated with several drugs. The aim of this study was to understand the level of genetic diversity in pfmrp1 and to determine the association of different mutations with altered drug susceptibilities of P. falciparum.

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