Comparison of planktonic and biofilm-associated communities of Clostridium difficile and indigenous gut microbiota in a triple-stage chemostat gut model | Zendy

G. S. Crowther | Zendy; C. H. Chilton | Zendy; S. L. Todhunter | Zendy; Scott Nicholson | Zendy; Jane Freeman | Zendy; Simon D. Baines | Zendy; M. H. Wilcox | Zendy

Open Access

Comparison of planktonic and biofilm-associated communities of Clostridium difficile and indigenous gut microbiota in a triple-stage chemostat gut model

Author(s) -

G. S. Crowther,

C. H. Chilton,

S. L. Todhunter,

Scott Nicholson,

Jane Freeman,

Simon D. Baines,

M. H. Wilcox

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku116

Subject(s) - microbiology and biotechnology , clostridium difficile , clindamycin , biology , biofilm , vancomycin , antibiotics , gut flora , clostridium difficile toxin a , colonization , bacteria , immunology , staphylococcus aureus , genetics

Biofilms are characteristic of some chronic or recurrent infections and this mode of growth tends to reduce treatment efficacy. Clostridium difficile infection (CDI) is associated with a high rate of recurrent symptomatic disease. The presence and behaviour of C. difficile within intestinal biofilms remains largely unexplored, but may factor in recurrent infection.

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