Effects of selective digestive decontamination (SDD) on the gut resistome | Zendy

Elena Buelow | Zendy; Teresita d. J. Bello Gonzalez | Zendy; Dennis Versluis | Zendy; Evelien Oostdijk | Zendy; Lesley A. Ogilvie | Zendy; Maaike S. M. van Mourik | Zendy; Els Oosterink | Zendy; Mark W. J. van Passel | Zendy; Hauke Smidt | Zendy; Marco Maria D’Andrea | Zendy; Mark de Been | Zendy; Brian V. Jones | Zendy; Rob J. L. Willems | Zendy; Marc J. M. Bonten | Zendy; Willem van Schaik | Zendy

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Effects of selective digestive decontamination (SDD) on the gut resistome

Author(s) -

Elena Buelow,

Teresita d. J. Bello Gonzalez,

Dennis Versluis,

Evelien Oostdijk,

Lesley A. Ogilvie,

Maaike S. M. van Mourik,

Els Oosterink,

Mark W. J. van Passel,

Hauke Smidt,

Marco Maria D’Andrea,

Mark de Been,

Brian V. Jones,

Rob J. L. Willems,

Marc J. M. Bonten,

Willem van Schaik

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku092

Subject(s) - resistome , antibiotics , microbiology and biotechnology , antibiotic resistance , flora (microbiology) , human decontamination , biology , intensive care , bacteria , medicine , intensive care medicine , pathology , genetics , integron

Selective digestive decontamination (SDD) is an infection prevention measure for critically ill patients in intensive care units (ICUs) that aims to eradicate opportunistic pathogens from the oropharynx and intestines, while sparing the anaerobic flora, by the application of non-absorbable antibiotics. Selection for antibiotic-resistant bacteria is still a major concern for SDD. We therefore studied the impact of SDD on the reservoir of antibiotic resistance genes (i.e. the resistome) by culture-independent approaches.

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