The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry | Zendy

Gerrit Gehring | Zendy; Katrin Rohrmann | Zendy; Nkacheh Atenchong | Zendy; Eva Mittler | Zendy; Stephan Becker | Zendy; Franziska Dahlmann | Zendy; Stefan Pöhlmann | Zendy; Florian W. R. Vondran | Zendy; Sascha David | Zendy; Michael P. Manns | Zendy; Sandra Ciesek | Zendy; Thomas von Hahn | Zendy

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The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

Author(s) -

Gerrit Gehring,

Katrin Rohrmann,

Nkacheh Atenchong,

Eva Mittler,

Stephan Becker,

Franziska Dahlmann,

Stefan Pöhlmann,

Florian W. R. Vondran,

Sascha David,

Michael P. Manns,

Sandra Ciesek,

Thomas von Hahn

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku091

Subject(s) - dronedarone , enfuvirtide , viral entry , amiodarone , pharmacology , entry inhibitor , virology , verapamil , arenavirus , biology , medicine , virus , viral replication , immunology , calcium , lymphocytic choriomeningitis , antigen , gp41 , cd8 , epitope , atrial fibrillation

Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic fever syndrome in humans for which there is no specific treatment. Since filoviruses use a complex route of cell entry that depends on numerous cellular factors, we hypothesized that there may be drugs already approved for human use for other indications that interfere with signal transduction or other cellular processes required for their entry and hence have anti-filoviral properties.

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