HIV-1 drug mutations in children from northern Tanzania | Zendy

Elichilia R. Shao | Zendy; Emanuel Kifaro | Zendy; Innocent Chilumba | Zendy; Balthazar Nyombi | Zendy; Sikhulile Moyo | Zendy; Simani Gaseitsiwe | Zendy; Rosemary Musonda | Zendy; Asgeir Johannessen | Zendy; Gibson Kibiki | Zendy; Max Essex | Zendy

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HIV-1 drug mutations in children from northern Tanzania

Author(s) -

Elichilia R. Shao,

Emanuel Kifaro,

Innocent Chilumba,

Balthazar Nyombi,

Sikhulile Moyo,

Simani Gaseitsiwe,

Rosemary Musonda,

Asgeir Johannessen,

Gibson Kibiki,

Max Essex

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku087

Subject(s) - nevirapine , tanzania , drug resistance , genotype , medicine , hiv drug resistance , dried blood spot , virology , viral load , transmission (telecommunications) , pediatrics , reverse transcriptase , human immunodeficiency virus (hiv) , biology , gene , antiretroviral therapy , genetics , polymerase chain reaction , environmental science , environmental planning , electrical engineering , engineering

In resource-limited settings, it is a challenge to get quality clinical specimens due to poor infrastructure for their collection, transportation, processing and storage. Using dried blood spots (DBS) might be an alternative to plasma for HIV-1 drug resistance testing in this setting. The objectives of this study were to determine mutations associated with antiretroviral resistance among children <18 months old born to HIV-1-infected mothers enrolled in prevention of mother-to-child transmission services in northern Tanzania.

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