In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPC-producing Klebsiella pneumoniae bloodstream isolates | Zendy

Paolo Gaibani | Zendy; Donatella Lombardo | Zendy; Russell E. Lewis | Zendy; Mathew Mercuri | Zendy; S. Bonora | Zendy; Maria Paola Landini | Zendy; Simone Ambretti | Zendy

Open Access

In vitro activity and post-antibiotic effects of colistin in combination with other antimicrobials against colistin-resistant KPC-producing Klebsiella pneumoniae bloodstream isolates

Author(s) -

Paolo Gaibani,

Donatella Lombardo,

Russell E. Lewis,

Mathew Mercuri,

S. Bonora,

Maria Paola Landini,

Simone Ambretti

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku065

Subject(s) - colistin , tigecycline , klebsiella pneumoniae , microbiology and biotechnology , acinetobacter baumannii , rifampicin , meropenem , etest , antibiotics , biology , carbapenem , antibiotic resistance , bacteria , pseudomonas aeruginosa , escherichia coli , gene , biochemistry , genetics

Combination therapy is recommended for the treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp), but the optimal regimen for colistin-resistant strains is unknown. We compared the synergistic activity and post-antibiotic effect (PAE) of colistin in combination with other antimicrobials against colistin-susceptible and -resistant KPC-Kp bloodstream isolates.

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