Nisin/β-lactam adjunct therapy against Salmonella enterica serovar Typhimurium: a mechanistic approach | Zendy

Aman Preet Singh | Zendy; Simran Preet | Zendy; Praveen Rishi | Zendy

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Nisin/β-lactam adjunct therapy against Salmonella enterica serovar Typhimurium: a mechanistic approach

Author(s) -

Aman Preet Singh,

Simran Preet,

Praveen Rishi

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku049

Subject(s) - nisin , salmonella enterica , salmonella , microbiology and biotechnology , cefotaxime , chemistry , membrane permeability , ceftriaxone , context (archaeology) , biology , biochemistry , antibiotics , bacteria , antimicrobial , membrane , paleontology , genetics

Multidrug resistance exhibited by Salmonella strains has proved to be a big hurdle in the development of an effective anti-Salmonella therapy. In this context, we had previously demonstrated strong synergism of nisin/ceftriaxone and nisin/cefotaxime combinations against Salmonella enterica serovar Typhimurium. However, the mechanism remained unexplored. The present study was therefore planned in order to evaluate the underlying mechanisms responsible for the synergistic effect of nisin in combination with these β-lactam antibiotics against serovar Typhimurium.

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