Novel non-neuroleptic phenothiazines inhibit Mycobacterium tuberculosis replication | Zendy

Sumayah Salie | Zendy; NaiJen Hsu | Zendy; Dorothy Semenya | Zendy; Anwar Jardine | Zendy; Muazzam Jacobs | Zendy

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Novel non-neuroleptic phenothiazines inhibit Mycobacterium tuberculosis replication

Author(s) -

Sumayah Salie,

NaiJen Hsu,

Dorothy Semenya,

Anwar Jardine,

Muazzam Jacobs

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku036

Subject(s) - antimycobacterial , phenothiazine , mycobacterium tuberculosis , pharmacology , cytotoxicity , chemistry , in vitro , biology , microbiology and biotechnology , biochemistry , tuberculosis , medicine , pathology

Phenothiazines are a commercially available class of psychotropic drugs known to show antituberculosis activity. At clinically relevant bactericidal doses, however, the psychotropic drugs produce undesirable side effects in addition to their neuroleptic properties. This study aimed to evaluate rationally designed novel phenothiazines as antimycobacterial drug candidates.

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