Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs | Zendy

Caroline Paulussen | Zendy; Kelly de Wit | Zendy; Gaëlle Boulet | Zendy; Paul Cos | Zendy; Lieven Meerpoel | Zendy; Louis Maes | Zendy

Open Access

Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs

Author(s) -

Caroline Paulussen,

Kelly de Wit,

Gaëlle Boulet,

Paul Cos,

Lieven Meerpoel,

Louis Maes

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku034

Subject(s) - microsporum canis , aspergillus fumigatus , in vivo , antiparasitic , ketoconazole , pharmacology , in vitro , microbiology and biotechnology , microsporum , dermatophyte , aspergillus flavus , antifungal , chemistry , trichophyton , biology , medicine , biochemistry , pathology

Pyrrolo[1,2-α][1,4]benzodiazepines (PBDs) have been described as a novel class of antifungal compounds with activity against dermatophytes and Aspergillus fumigatus. The initial structure-activity relationship showed that compounds with a chlorine substitution at position 7 have a higher activity compared with regioisomers or other substituents.

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