Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS) | Zendy

Consuelo Viladés | Zendy; Xavier Escoté | Zendy; Miguel López-Dupla | Zendy; Estebán Martínez | Zendy; Peré Domingo | Zendy; Víctor Asensi | Zendy; Manuel Leal | Zendy; Joaquim Peraire | Zendy; Maria-Isabel Inza | Zendy; Mireia Arnedo | Zendy; Mar Gutiérrez | Zendy; Eulalia Valle-Garay | Zendy; Sara FerrandoMartínez | Zendy; Montserrat Olona | Zendy; Verónica Alba | Zendy; Juan J. Sirvent | Zendy; Josep M. Gatell | Zendy; Francesc Vidal | Zendy; Alba Aguilar | Zendy; Montserrat Vargas | Zendy; Àngels Fontanet | Zendy; Gràcia Mateo | Zendy; Jessica Muñoz | Zendy; M. A. Sambeat | Zendy; Lander Egaña-Gorrondo | Zendy

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Involvement of the LPS-LPB-CD14-MD2-TLR4 inflammation pathway in HIV-1/HAART-associated lipodystrophy syndrome (HALS)

Author(s) -

Consuelo Viladés,

Xavier Escoté,

Miguel López-Dupla,

Estebán Martínez,

Peré Domingo,

Víctor Asensi,

Manuel Leal,

Joaquim Peraire,

Maria-Isabel Inza,

Mireia Arnedo,

Mar Gutiérrez,

Eulalia Valle-Garay,

Sara FerrandoMartínez,

Montserrat Olona,

Verónica Alba,

Juan J. Sirvent,

Josep M. Gatell,

Francesc Vidal,

Alba Aguilar,

Montserrat Vargas,

Àngels Fontanet,

Gràcia Mateo,

Jessica Muñoz,

M. A. Sambeat,

Lander Egaña-Gorrondo

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku032

Subject(s) - lipopolysaccharide binding protein , medicine , lipodystrophy , gastroenterology , cd14 , immunology , genotype , genotyping , viral load , endocrinology , human immunodeficiency virus (hiv) , biology , antiretroviral therapy , receptor , gene , biochemistry

A relationship between obesity and intestinal bacterial translocation has been reported. Very little information is available with respect to the involvement of the bacterial translocation mechanistic pathway in HIV-1/highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome (HALS). We determined whether lipopolysaccharide (LPS)-binding protein (LBP), cluster of differentiation 14 (CD14), myeloid differentiation protein 2 (MD2) and toll-like receptor 4 (TLR4) single-nucleotide polymorphisms and LPS, LBP and soluble CD14 (sCD14) plasma levels are involved in HALS.

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