Open AccessUnderstanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing
Author(s) -
Michael Dolton,
Gerd Mikus,
Johanna Weiß,
John E. Ray,
Andrew J. McLachlan
Publication year - 2014
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dku031
Subject(s) - voriconazole , cyp2c19 , pharmacokinetics , dosing , pharmacology , medicine , population , cytochrome p450 , antifungal , environmental health , dermatology , metabolism
Voriconazole exhibits highly variable, non-linear pharmacokinetics and is associated with a narrow therapeutic range. This study aimed to investigate the population pharmacokinetics of voriconazole in adults, including the effect of CYP2C19 genotype and drug-drug interactions.
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