Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains | Zendy

Chao Wang | Zendy; Weiguo Shi | Zendy; Lifeng Cai | Zendy; Lu Lu | Zendy; Fei Yu | Zendy; Qian Wang | Zendy; Xifeng Jiang | Zendy; Xiaoyu Xu | Zendy; Kun Wang | Zendy; Liang Xu | Zendy; Shibo Jiang | Zendy; Keliang Liu | Zendy

Open Access

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains

Author(s) -

Chao Wang,

Weiguo Shi,

Lifeng Cai,

Lu Lu,

Fei Yu,

Qian Wang,

Xifeng Jiang,

Xiaoyu Xu,

Kun Wang,

Liang Xu,

Shibo Jiang,

Keliang Liu

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dku010

Subject(s) - enfuvirtide , human immunodeficiency virus (hiv) , biology , virology , heptad repeat , peptide , chemistry , gp41 , biochemistry , peptide sequence , immunology , antibody , epitope , gene

To develop new HIV-1 fusion inhibitors with improved antiviral activities and resistance profiles, we designed two categories of artificial peptides, each containing four heptad repeats (m4HR) conjugated with a pocket-specific small molecule (pssm) or pssm and cholesterol (chol), designated pssm-m4HR or pssm-m4HR-chol, respectively, and tested their anti-HIV-1 activity.

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