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Erm(41)-dependent inducible resistance to azithromycin and clarithromycin in clinical isolates of Mycobacterium abscessus
Author(s) -
Florian P. Maurer,
Claudio Castelberg,
Catherine Quiblier,
Erik C. Böttger,
Ákos Somoskövi
Publication year - 2014
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dku007
Subject(s) - clarithromycin , azithromycin , mycobacterium abscessus , microbiology and biotechnology , mycobacterium chelonae , broth microdilution , antibiotics , drug resistance , minimum inhibitory concentration , antibacterial agent , mycobacterium , 23s ribosomal rna , medicine , biology , bacteria , gene , genetics , ribosome , rna
The ribosomal methylase Erm(41) confers inducible resistance to macrolides in Mycobacterium abscessus. The aim of this work was to systematically study and compare drug susceptibility to clarithromycin and azithromycin in M. abscessus and Mycobacterium chelonae clinical isolates with a particular focus on inducible drug resistance.

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