Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex | Zendy

Silke Feuerriegel | Zendy; Claudio U. Köser | Zendy; Stefan Niemann | Zendy

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Phylogenetic polymorphisms in antibiotic resistance genes of the Mycobacterium tuberculosis complex

Author(s) -

Silke Feuerriegel,

Claudio U. Köser,

Stefan Niemann

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt535

Subject(s) - biology , mycobacterium tuberculosis , ethambutol , mycobacterium tuberculosis complex , genotype , antibiotic resistance , genetics , microbiology and biotechnology , context (archaeology) , multilocus sequence typing , rifampicin , tuberculosis , antibiotics , gene , medicine , paleontology , pathology

Sequence analysis of known antibiotic resistance genes of the Mycobacterium tuberculosis complex (MTBC) is increasingly being used to infer phenotypic resistance to a variety of antibiotics. However, a clear understanding of the genotype-phenotype relationship is required to interpret genotypic susceptibility results accurately. In this context, it is particularly important to distinguish phylogenetically informative neutral polymorphisms from true resistance-conferring mutations.

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