Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates | Zendy

Roosmarijn F. W. De Cock | Zendy; Anne Smits | Zendy; Karel Allegaert | Zendy; Jan de Hoon | Zendy; Veroniek Saegeman | Zendy; Meindert Danhof | Zendy; Catherijne A. J. Knibbe | Zendy

Open Access

Population pharmacokinetic modelling of total and unbound cefazolin plasma concentrations as a guide for dosing in preterm and term neonates

Author(s) -

Roosmarijn F. W. De Cock,

Anne Smits,

Karel Allegaert,

Jan de Hoon,

Veroniek Saegeman,

Meindert Danhof,

Catherijne A. J. Knibbe

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt527

Subject(s) - dosing , cefazolin , pharmacokinetics , medicine , population pharmacokinetics , population , pharmacology , antibiotics , anesthesia , biology , microbiology and biotechnology , environmental health

Cefazolin is frequently administered for antimicrobial prophylaxis and treatment of infections. In neonates, pharmacokinetic observations are limited and dosing regimens variable. The aim of this study was to describe the pharmacokinetics of cefazolin in neonates based on total and unbound concentrations to optimize cefazolin dosing.

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