A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing | Zendy

Ami Fazlin Syed Mohamed | Zendy; Otto Cars | Zendy; Lena E. Friberg | Zendy

Open Access

A pharmacokinetic/pharmacodynamic model developed for the effect of colistin on Pseudomonas aeruginosa in vitro with evaluation of population pharmacokinetic variability on simulated bacterial killing

Author(s) -

Ami Fazlin Syed Mohamed,

Otto Cars,

Lena E. Friberg

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt520

Subject(s) - colistin , pseudomonas aeruginosa , pharmacokinetics , pharmacology , pharmacodynamics , population , dosing , antibiotics , minimum inhibitory concentration , microbiology and biotechnology , medicine , chemistry , biology , bacteria , genetics , environmental health

An optimized dosing regimen of the prodrug of colistin, colistin methanesulphonate (CMS), against resistant Pseudomonas aeruginosa is needed to ensure effective bacterial killing. The objectives of this study were to develop a pharmacokinetic (PK)/pharmacodynamic (PD) model that characterizes the time course of the antibacterial activity of colistin against P. aeruginosa in a static in vitro system and to perform simulations of different dosing regimens and dosing algorithms to evaluate the effect of interindividual variability and interoccasion variability in PK on bacterial killing.

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