Disposition of amodiaquine and desethylamodiaquine in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy | Zendy

Kimberly K. Scarsi | Zendy; F.A. Fehintola | Zendy; Qing Ma | Zendy; Francesca Aweeka | Zendy; K. M. Darin | Zendy; G. D. Morse | Zendy; Ibrahim Tope Akinola | Zendy; Waheed Adeola Adedeji | Zendy; Niklas Lindegårdh | Zendy; Joel Tärning | Zendy; Oladosu Ojengbede | Zendy; Isaac F. Adewole | Zendy; Babafemi Taiwo | Zendy; Robert L. Murphy | Zendy; O. O. Akinyinka | Zendy; Sunil Parikh | Zendy

Open Access

Disposition of amodiaquine and desethylamodiaquine in HIV-infected Nigerian subjects on nevirapine-containing antiretroviral therapy

Author(s) -

Kimberly K. Scarsi,

F.A. Fehintola,

Qing Ma,

Francesca Aweeka,

K. M. Darin,

G. D. Morse,

Ibrahim Tope Akinola,

Waheed Adeola Adedeji,

Niklas Lindegårdh,

Joel Tärning,

Oladosu Ojengbede,

Isaac F. Adewole,

Babafemi Taiwo,

Robert L. Murphy,

O. O. Akinyinka,

Sunil Parikh

Publication year - 2014

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt513

Subject(s) - nevirapine , amodiaquine , medicine , antiretroviral therapy , human immunodeficiency virus (hiv) , virology , pharmacology , immunology , viral load , malaria , plasmodium falciparum

Artesunate plus amodiaquine is used for malaria treatment in regions with overlapping HIV endemicity. Co-administration of artesunate/amodiaquine with antiretroviral therapy (ART) may result in drug-drug interactions, but minimal data exist. This study evaluated the impact of nevirapine-based ART, containing a backbone of zidovudine and lamivudine, on the disposition of amodiaquine and its active metabolite, desethylamodiaquine (DEAQ).

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