Open AccessPharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application
Author(s) -
Karl Malcolm,
Donal Lowry,
Peter D. W. Boyd,
Laura A. Geer,
Ronald S. Veazey,
Lynn R. Goldman,
Per Johan Klasse,
Robin J. Shattock,
John P. Moore
Publication year - 2013
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt506
Subject(s) - pharmacokinetics , rectal administration , medicine , human immunodeficiency virus (hiv) , microbicide , pharmacology , oral administration , virology
This study measured and compared the pharmacokinetics of CMPD167, a small molecule antiretroviral CCR5 inhibitor with potential as an HIV microbicide, following vaginal, rectal and oral administration in rhesus macaques.
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