Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential | Zendy

Thomas Antoine | Zendy; Nicholas Fisher | Zendy; Richard K. Amewu | Zendy; Paul M. O’Neill | Zendy; Stephen A. Ward | Zendy; Giancarlo A. Biagini | Zendy

Open Access

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

Author(s) -

Thomas Antoine,

Nicholas Fisher,

Richard K. Amewu,

Paul M. O’Neill,

Stephen A. Ward,

Giancarlo A. Biagini

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt486

Subject(s) - artemisinin , malaria , depolarization , plasmodium falciparum , membrane potential , microbiology and biotechnology , chemistry , biology , biophysics , immunology

Artemisinin and artemisinin semi-synthetic derivatives (collectively known as endoperoxides) are first-line antimalarials for the treatment of uncomplicated and severe malaria. Endoperoxides display very fast killing rates and are generally recalcitrant to parasite resistance development. These key pharmacodynamic features are a result of a complex mechanism of action, the details of which lack consensus. Here, we report on the primary physiological events leading to parasite death.

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