Pharmacokinetic interaction of rifapentine and raltegravir in healthy volunteers
Author(s) -
Marc Weiner,
Eric F. Egelund,
Melissa Engle,
Melanie N. Kiser,
Thomas J. Prihoda,
Jon Gelfond,
William Mac Kenzie,
Charles A. Peloquin
Publication year - 2013
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt483
Subject(s) - raltegravir , rifapentine , pharmacokinetics , pharmacology , medicine , posaconazole , tuberculosis , latent tuberculosis , human immunodeficiency virus (hiv) , antifungal , mycobacterium tuberculosis , virology , itraconazole , viral load , antiretroviral therapy , pathology , dermatology
Latent tuberculosis infection and tuberculosis disease are prevalent worldwide. However, antimycobacterial rifamycins have drug interactions with many antiretroviral drugs. We evaluated the effect of rifapentine on the pharmacokinetic properties of raltegravir.
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