Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization
Author(s) -
Alvin W. Lo,
Karen Van de Water,
Paul J. Gane,
A. W. Edith Chan,
David Steadman,
Kiri Stevens,
David L. Selwood,
Gabriel Waksman,
Han Remaut
Publication year - 2013
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkt467
Subject(s) - pilus , protein subunit , fimbriae proteins , escherichia coli , biology , biofilm , microbiology and biotechnology , fimbria , chaperone (clinical) , virulence , biogenesis , bacteria , biochemistry , genetics , gene , medicine , pathology
To identify and to characterize small-molecule inhibitors that target the subunit polymerization of the type 1 pilus assembly in uropathogenic Escherichia coli (UPEC).
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