Comparative in vitro activity of sulfametrole/trimethoprim and sulfamethoxazole/trimethoprim and other agents against multiresistant Gram-negative bacteria | Zendy

David M. Livermore | Zendy; Shazad Mushtaq | Zendy; M. Warner | Zendy; N. Woodford | Zendy

Open Access

Comparative in vitro activity of sulfametrole/trimethoprim and sulfamethoxazole/trimethoprim and other agents against multiresistant Gram-negative bacteria

Author(s) -

David M. Livermore,

Shazad Mushtaq,

M. Warner,

N. Woodford

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt455

Subject(s) - trimethoprim , microbiology and biotechnology , stenotrophomonas maltophilia , sulfamethoxazole , biology , antibiotics , pseudomonas aeruginosa , bacteria , genetics

Sulfamethoxazole/trimethoprim is standard therapy for infections caused by opportunist non-fermenters except Pseudomonas aeruginosa and Acinetobacter. Sulfametrol(e)/trimethoprim is an alternative to sulfamethoxazole/trimethoprim available in some EU countries, with possible pharmacological advantages. We compared their activities against (i) non-fermenters, (ii) multiresistant Enterobacteriaceae and (iii) reference strains with sul1 and sul2.

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