GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus | Zendy

Mary Ann De Groote | Zendy; LaRue W. Johnson | Zendy; Brendan K. Podell | Zendy; Elizabeth J. Brooks | Zendy; Randall J. Basaraba | Zendy; Mercedes GonzalezJuarrero | Zendy

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GM-CSF knockout mice for preclinical testing of agents with antimicrobial activity against Mycobacterium abscessus

Author(s) -

Mary Ann De Groote,

LaRue W. Johnson,

Brendan K. Podell,

Elizabeth J. Brooks,

Randall J. Basaraba,

Mercedes GonzalezJuarrero

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt451

Subject(s) - mycobacterium abscessus , medicine , azithromycin , antimicrobial , nontuberculous mycobacteria , immunology , lung , antibiotics , mycobacterium , pathology , microbiology and biotechnology , tuberculosis , biology

Of the non-tuberculous mycobacteria, Mycobacterium abscessus is particularly refractory to antimicrobial therapy and new agents with activity against these pathogens are urgently needed. The screening of candidate antimicrobial agents against M. abscessus requires a relevant and reproducible animal model of chronic infection. Granulocyte-macrophage colony-stimulating factor knockout (GM-CSF KO) mice were used to develop a new animal model of chronic pulmonary M. abscessus infection that can be used for preclinical efficacy testing of antimicrobial drugs.

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