Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis | Zendy

Margreke J. E. Brill | Zendy; Aletta P. I. Houwink | Zendy; Stephan Schmidt | Zendy; E.P.A. van Dongen | Zendy; Eric J. Hazebroek | Zendy; Bert van Ramshorst | Zendy; Vera H.M. Deneer | Zendy; Johan W. Mouton | Zendy; Catherijne A. J. Knibbe | Zendy

Open Access

Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis

Author(s) -

Margreke J. E. Brill,

Aletta P. I. Houwink,

Stephan Schmidt,

E.P.A. van Dongen,

Eric J. Hazebroek,

Bert van Ramshorst,

Vera H.M. Deneer,

Johan W. Mouton,

Catherijne A. J. Knibbe

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt444

Subject(s) - cefazolin , microdialysis , medicine , pharmacokinetics , morbidly obese , adipose tissue , body mass index , anesthesia , nonmem , volume of distribution , subcutaneous tissue , urology , surgery , obesity , antibiotics , chemistry , weight loss , biochemistry , central nervous system

As morbidly obese patients are prone to surgical site infections, adequate blood and subcutaneous tissue concentrations of prophylactic antibiotic agents during surgery are imperative. In this study we evaluated cefazolin subcutaneous adipose tissue distribution in morbidly obese and non-obese patients, thereby quantifying the influence of morbid obesity on cefazolin pharmacokinetics and enabling Monte Carlo simulations for subsequent dose adjustments.

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