Inhibition of multidrug efflux as a strategy to prevent biofilm formation | Zendy

Simon D. P. Baugh | Zendy; Colin R. Phillips | Zendy; A. S. Ekanayaka | Zendy; Laura J. V. Piddock | Zendy; Mark Webber | Zendy

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Inhibition of multidrug efflux as a strategy to prevent biofilm formation

Author(s) -

Simon D. P. Baugh,

Colin R. Phillips,

A. S. Ekanayaka,

Laura J. V. Piddock,

Mark Webber

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt420

Subject(s) - biofilm , efflux , salmonella enterica , microbiology and biotechnology , pseudomonas aeruginosa , mutant , salmonella , biology , bacteria , multiple drug resistance , chemistry , multidrug tolerance , biochemistry , antibiotics , gene , genetics

We have recently shown that inactivation of any of the multidrug efflux systems of Salmonella results in loss of the ability to form a competent biofilm. The aim of this study was to determine the mechanism linking multidrug efflux and biofilm formation, and to determine whether inhibition of efflux is a viable antibiofilm strategy.

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