Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India | Zendy

Anuradha Chowdhary | Zendy; Cheshta Sharma | Zendy; Shallu Kathuria | Zendy; Ferry Hagen | Zendy; Jacques F. Meis | Zendy

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Azole-resistant Aspergillus fumigatus with the environmental TR46/Y121F/T289A mutation in India

Author(s) -

Anuradha Chowdhary,

Cheshta Sharma,

Shallu Kathuria,

Ferry Hagen,

Jacques F. Meis

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt397

Subject(s) - aspergillus fumigatus , azole , microbiology and biotechnology , biology , mutation , aspergillosis , aspergillus , virology , antifungal , genetics , immunology , gene

resistant A. fumigatus strains originated from Varanasi, five from a potato (Solanum tuberosum) field and one from a fenugreek (Trigonella foenum-graecum) field, which were located 2 km apart from each other. Four of the eight itraconazole-resistant A. fumigatus strains originated from rose (Rosa species) bed soil and red chilli (Capsicum annuum) fields, Delhi. Of the remaining four itraconazole-resistant A. fumigatus strains, one each originated from fields of aubergine (Solanum melongena), mustard (Brassica juncea), potato and fenugreek in Varanasi. Notably, 5.7% of the soil samples harboured voriconazole-resistant A. fumigatus and 7.6% harboured itraconazole-resistant A. fumigatus. The overall isolation rate of both itraconazole- and voriconazole-resistant A. fumigatus was found to be higher in Varanasi (26.3%; 10/38) than in Delhi (4.5%; 4/88). Identification of resistant A. fumigatus strains was confirmed by sequencing of the internal transcribed spacer region,

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