Genomic identification of a novel co-trimoxazole resistance genotype and its prevalence amongst Streptococcus pneumoniae in Malawi | Zendy

Jennifer Cornick | Zendy; Simon R. Harris | Zendy; Christopher M. Parry | Zendy; Matthew Moore | Zendy; Chikondi Jassi | Zendy; Arox W. Kamng’ona | Zendy; Benard W. Kulohoma | Zendy; Robert S. Heyderman | Zendy; Stephen D. Bentley | Zendy; Dean Everett | Zendy

Open Access

Genomic identification of a novel co-trimoxazole resistance genotype and its prevalence amongst Streptococcus pneumoniae in Malawi

Author(s) -

Jennifer Cornick,

Simon R. Harris,

Christopher M. Parry,

Matthew Moore,

Chikondi Jassi,

Arox W. Kamng’ona,

Benard W. Kulohoma,

Robert S. Heyderman,

Stephen D. Bentley,

Dean Everett

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt384

Subject(s) - sulfadoxine , trimethoprim , streptococcus pneumoniae , pyrimethamine , dihydrofolate reductase , genotype , microbiology and biotechnology , virology , sulfamethoxazole , biology , pneumococcal infections , drug resistance , genetics , antibiotics , malaria , plasmodium falciparum , immunology , gene

This study aimed to define the molecular basis of co-trimoxazole resistance in Malawian pneumococci under the dual selective pressure of widespread co-trimoxazole and sulfadoxine/pyrimethamine use.

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