Identification of factors influencing the pharmacokinetics of voriconazole and the optimization of dosage regimens based on Monte Carlo simulation in patients with invasive fungal infections | Zendy

T. Wang | Zendy; Shiping Chen | Zendy; Jing Sun | Zendy; Jie Cai | Zendy; Xiaoliang Cheng | Zendy; Haiyan Dong | Zendy; Xishan Wang | Zendy; Jianfeng Xing | Zendy; Wenqi Dong | Zendy; Hong Yao | Zendy; Yunxia Dong | Zendy

Open Access

Identification of factors influencing the pharmacokinetics of voriconazole and the optimization of dosage regimens based on Monte Carlo simulation in patients with invasive fungal infections

Author(s) -

T. Wang,

Shiping Chen,

Jing Sun,

Jie Cai,

Xiaoliang Cheng,

Haiyan Dong,

Xishan Wang,

Jianfeng Xing,

Wenqi Dong,

Hong Yao,

Yunxia Dong

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt369

Subject(s) - voriconazole , pharmacokinetics , medicine , pharmacology , population , pharmacodynamics , cyp2c19 , nonmem , regimen , antifungal , environmental health , cytochrome p450 , dermatology , metabolism

The objective of this study was to estimate the population pharmacokinetics of voriconazole, to identify the factors influencing voriconazole pharmacokinetics and to identify optimal dosage regimens for attaining target pharmacokinetic/pharmacodynamic indices against Aspergillus and Candida infections in patients with invasive fungal infections (IFIs).

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