Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions | Zendy

Aline T. Marinho | Zendy; Paulo Rodrigues | Zendy; Umbelina Caixas | Zendy; Alexandra M. M. Antunes | Zendy; Teresa Branco | Zendy; Shrika G. Harjivan | Zendy; M. Matilde Marques | Zendy; Emília C. Monteiro | Zendy; Sofia A. Pereira | Zendy

Open Access

Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions

Author(s) -

Aline T. Marinho,

Paulo Rodrigues,

Umbelina Caixas,

Alexandra M. M. Antunes,

Teresa Branco,

Shrika G. Harjivan,

M. Matilde Marques,

Emília C. Monteiro,

Sofia A. Pereira

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt359

Subject(s) - nevirapine , metabolite , pharmacology , toxicity , medicine , physiology , biology , immunology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy

Nevirapine is widely used for the treatment of HIV-1 infection; however, its chronic use has been associated with severe liver and skin toxicity. Women are at increased risk for these toxic events, but the reasons for the sex-related differences are unclear. Disparities in the biotransformation of nevirapine and the generation of toxic metabolites between men and women might be the underlying cause. The present work aimed to explore sex differences in nevirapine biotransformation as a potential factor in nevirapine-induced toxicity.

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