Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis | Zendy

Hanebenzahl-Guimaraes | Zendy; Karen R. Jacobson | Zendy; Maha Farhat | Zendy; Megan Murray | Zendy

Open Access

Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis

Author(s) -

Hanebenzahl-Guimaraes,

Karen R. Jacobson,

Maha Farhat,

Megan Murray

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt358

Subject(s) - mycobacterium tuberculosis , genetics , drug resistance , biology , rpob , tuberculosis , inha , phenotype , ethambutol , mutation , isoniazid , allele , gene , medicine , rifampicin , antibiotics , 16s ribosomal rna , pathology

Improving our understanding of the relationship between the genotype and the drug resistance phenotype of Mycobacterium tuberculosis will aid the development of more accurate molecular diagnostics for drug-resistant tuberculosis. Studies that use direct genetic manipulation to identify the mutations that cause M. tuberculosis drug resistance are superior to associational studies in elucidating an individual mutation's contribution to the drug resistance phenotype.

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