High interpatient variability of raltegravir CSF concentrations in HIV-positive patients: a pharmacogenetic analysis | Zendy

Andrea Calcagno | Zendy; Jessica Cusato | Zendy; Marco Simiele | Zendy; Ilaria Motta | Zendy; Sabrina Audagnotto | Zendy; Margherita Bracchi | Zendy; Antonio D’Avolio | Zendy; Giovanni Di Perri | Zendy; Stefano Bonora | Zendy

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High interpatient variability of raltegravir CSF concentrations in HIV-positive patients: a pharmacogenetic analysis

Author(s) -

Andrea Calcagno,

Jessica Cusato,

Marco Simiele,

Ilaria Motta,

Sabrina Audagnotto,

Margherita Bracchi,

Antonio D’Avolio,

Giovanni Di Perri,

Stefano Bonora

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt339

Subject(s) - raltegravir , pharmacokinetics , medicine , pharmacology , probenecid , integrase inhibitor , pharmacogenetics , therapeutic drug monitoring , dolutegravir , trough level , gastroenterology , genotype , viral load , chemistry , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , gene , biochemistry , transplantation , tacrolimus

To analyse the determinants of raltegravir CSF penetration, including the pharmacogenetics of drug transporters located at the blood-brain barrier or blood-CSF barrier.

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