Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival | Zendy

María Adelaida Gómez | Zendy; Adriavas | Zendy; Ricardo Márquez | Zendy; Laura Rojas-López | Zendy; Deninson Alejandro Vargas | Zendy; V. M. Blanco | Zendy; Roni Koren | Zendy; Dan Zilberstein | Zendy; Nancy Gore Saravia | Zendy

Open Access

Leishmania panamensis infection and antimonial drugs modulate expression of macrophage drug transporters and metabolizing enzymes: impact on intracellular parasite survival

Author(s) -

María Adelaida Gómez,

Adriavas,

Ricardo Márquez,

Laura Rojas-López,

Deninson Alejandro Vargas,

V. M. Blanco,

Roni Koren,

Dan Zilberstein,

Nancy Gore Saravia

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt334

Subject(s) - intracellular , meglumine antimoniate , intracellular parasite , leishmania , biology , pharmacology , cutaneous leishmaniasis , microbiology and biotechnology , leishmaniasis , immunology , parasite hosting , world wide web , computer science

Treatment failure is multifactorial. Despite the importance of host cell drug transporters and metabolizing enzymes in the accumulation, distribution and metabolism of drugs targeting intracellular pathogens, their impact on the efficacy of antileishmanials is unknown. We examined the contribution of pharmacologically relevant determinants in human macrophages in the antimony-mediated killing of intracellular Leishmania panamensis and its relationship with the outcome of treatment with meglumine antimoniate.

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