De novo generation of short antimicrobial peptides with enhanced stability and cell specificity | Zendy

HyunAh Kim | Zendy; Jinho Jang | Zendy; Seungchul Kim | Zendy; J. H. Cho | Zendy

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De novo generation of short antimicrobial peptides with enhanced stability and cell specificity

Author(s) -

HyunAh Kim,

Jinho Jang,

Seungchul Kim,

J. H. Cho

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt322

Subject(s) - antimicrobial , antimicrobial peptides , bacteria , staphylococcus aureus , microbiology and biotechnology , antibiotics , biochemistry , cytotoxicity , peptide , antibacterial activity , biology , viability assay , chemistry , in vitro , genetics

Though antimicrobial peptides (AMPs) show great potential as novel antibiotics, therapeutic applications are hindered by their low stability, toxicity and high manufacturing cost. Various chemical modification strategies are employed to overcome these problems. However, chemical modifications often significantly increase the manufacturing cost of AMPs with only limited pharmacokinetic advantages. Therefore, we developed AMPs with enhanced stability and cell specificity that can be economically produced.

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