Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing -lactamase derived from Haemophilus influenzae | Zendy

Viveka Schaar | Zendy; Ida Uddbäck | Zendy; Tobias Nordström | Zendy; Kristian Riesbeck | Zendy

Open Access

Group A streptococci are protected from amoxicillin-mediated killing by vesicles containing -lactamase derived from Haemophilus influenzae

Author(s) -

Viveka Schaar,

Ida Uddbäck,

Tobias Nordström,

Kristian Riesbeck

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt307

Subject(s) - haemophilus influenzae , microbiology and biotechnology , amoxicillin , haemophilus , pasteurellaceae , antibiotics , biology , bacteria , genetics

Group A streptococci (GAS) cause, among other infections, pharyngotonsillitis in children. The species is frequently localized with the Gram-negative respiratory pathogens non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis, which both produce outer membrane vesicles (OMVs). The aim of this study was to investigate whether OMVs isolated from NTHi contain functional β-lactamase and whether the OMVs hydrolyse amoxicillin and thus protect GAS from killing by the antibiotic.

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