A multicentre evaluation of the effectiveness and safety of high-dose daptomycin for the treatment of infective endocarditis | Zendy

Ravina Kullar | Zendy; Anthony M. Casapao | Zendy; Susan L. Davis | Zendy; Donald P. Levine | Zendy; Jingjing Zhao | Zendy; Christopher W. Crank | Zendy; John Segreti | Zendy; George Sakoulas | Zendy; Sara E. Cosgrove | Zendy; Michael J. Rybak | Zendy

Open Access

A multicentre evaluation of the effectiveness and safety of high-dose daptomycin for the treatment of infective endocarditis

Author(s) -

Ravina Kullar,

Anthony M. Casapao,

Susan L. Davis,

Donald P. Levine,

Jingjing Zhao,

Christopher W. Crank,

John Segreti,

George Sakoulas,

Sara E. Cosgrove,

Michael J. Rybak

Publication year - 2013

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkt294

Subject(s) - daptomycin , infective endocarditis , medicine , endocarditis , antibacterial agent , intensive care medicine , antibiotics , vancomycin , staphylococcus aureus , microbiology and biotechnology , biology , bacteria , genetics

Despite significant medical advances, infective endocarditis (IE) remains an infection associated with high morbidity and mortality. The objective was to assess the safety and efficacy of high-dose daptomycin, defined as ≥ 8 mg/kg/day, in patients with confirmed or suspected staphylococcal and/or enterococcal IE.

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